Chemical genetic methods for studying protein kinases

Electron tomographic methods for studying the chemical synapse.

OL. 79 0091 reserved. 241 DOI: 10.1016/S0091 -679X -679X II. N eurons, Neural Networks, and the Synapse III. E T and the Synapse IV. T ypes of Neurons and Synapses A. N euromuscular Junction Synapse B. R ibbon Synapses C. C NS Synapses V. S ources of Neurons for Structural Studies VI. M ethods for Assessing Neuron and Synapse Integrity V II. R apid Freezing and HPF of Neurons V III. M odeling a...

Chemical genetic strategy for targeting protein kinases based on covalent complementarity.

The conserved nature of the ATP-binding site of the > 500 human kinases renders the development of specific inhibitors a challenging task. A widely used chemical genetic strategy to overcome the specificity challenge exploits a large-to-small mutation of the gatekeeper residue (a conserved hydrophobic amino acid) and the use of a bulky inhibitor to achieve specificity via shape complementarity....

GANESH BABU MANOHARAN Combining chemical and genetic approaches for photoluminescence assays of protein kinases

Creating chemical diversity to target protein kinases.

Protein kinases play crucial roles in regulating virtually every cellular process and are currently attracting tremendous interest as drug targets from the pharmaceutical industry. The major challenges facing the development of the potential kinase inhibitor drugs are: selectivity, physical properties (solubility, molecular weight), and pharmacological properties (bioavailability, half life, to...

islanding detection methods for microgrids

امروزه استفاده از منابع انرژی پراکنده کاربرد وسیعی یافته است . اگر چه این منابع بسیاری از مشکلات شبکه را حل می کنند اما زیاد شدن آنها مسائل فراوانی برای سیستم قدرت به همراه دارد . استفاده از میکروشبکه راه حلی است که علاوه بر استفاده از مزایای منابع انرژی پراکنده برخی از مشکلات ایجاد شده توسط آنها را نیز منتفی می کند . همچنین میکروشبکه ها کیفیت برق و قابلیت اطمینان تامین انرژی مشترکان را افزایش ...